•CART Fund by-laws require that 100% of all donated funds must go to Alzheimer's research. The goal of the CART Fund is to encourage exploratory and developmental Alzheimer's Disease research projects within the United States. This is accomplished by providing financial support for the early and conceptual plans of those research projects that may not yet be supported by extensive preliminary data but have the potential to substantially advance biomedical research. These research projects should be distinct from those designed to increase knowledge in a well-established area unless they intend to extend previous discoveries toward new directions or applications.